Ireland hand a full debut to fly-half Billy Burns as part of an experimental line-up.
Burns, who came off the bench in the win over Wales and subsequent defeat to England, is among nine changes to head coach Andy Farrell’s starting XV.
The former England Under-20 international replaces Ross Byrne and will line up behind experienced scrum-half Conor Murray, who has been recalled following two consecutive appearances from the bench.
Centre Stuart McCloskey will make his first international appearance in two years to win his fourth cap, while Australia-born prop Finlay Bealham has been handed a rare opportunity to impress from the start.
Ireland starting XV: J Stockdale; K Earls, C Farrell, S McCloskey, H Keenan; B Burns, C Murray; F Bealham, R Herring, A Porter, I Henderson, Ja Ryan (capt), T Beirne, W Connors, CJ Stander.
Replacements: D Heffernan, C Healy, Jo Ryan, Q Roux, P O’Mahony, K Marmion, R Byrne, S Daly.
Soso Matiashvili returns at full-back as one of six changes for struggling Georgia ahead of their final Autumn Nations Cup Group A game against Ireland in Dublin on Sunday.
Coach Levan Maisashvili has also changed four members of the forward pack, with Shalva Mamukashvili coming in at hooker between props Mikheil Nariashvili and Beka Gigashvili.
There is an all-new second row as Nodar Cheishvili returns from injury to start alongside Lasha Jaiani, with Kote Mikautadze failing to recover from a rib injury sustained against Wales.
Georgia starting XV: S Matiashvili, A Tabutsadze, G Kveseladze, M Sharikadze (capt), T Mchedlidze, T Abzhandadze, V Lobzhanidze; M Nariashvili. S Mamukashvili, B Gigashvili, N Cheishvili, L Jaiani, B Saginadze,T Jalagonia, B Gorgadze.
Replacements: G Chkoidze, L Kaulashvili, G Melikidze, G Javakhia, M Gachechiladze, M Alania, D Tapladze, D Niniashvili.